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Contd…Freeze granulation TechnologySteam GranulationMelt Extrusion TechnologyLiquisolid TechniqueTOPO TechnologyCont...

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1. TABLETS General chapter 2. TABLETS • Tablets are solid dosage form each containing a unit dost of one or more medicament • Intended for oral administration • Some tablets are swallowed whole or after being chewed • some are dissolved or dispersed in water before administration • some are retained in the mouth where the active ingredient is liberated. 3. TABLETS • Because of their composition, method of manufacture or intended use, tablets present a variety of characteristics and consequently there are several categories of tablets. • Unless otherwise stated in the individual monograph, tablets are uncoated. 4. Different types of tablets • Uncoated tablets • Film Coated • Sugar Coated • Dispersible Tablets • Effervescent Tablets • Modified-release Tablets • Enteric-coated Tablets • Prolonged- release Tablets • Soluble Tablets • Tablets for Use in the Mouth
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I.P LIMIT

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Tablet weight is mainly affected by factors such as tooling of the compression machine,head pressure,machine speed and flow properties of the powder.Inconsistent powder or granulate density and particle size distribution are common sources of weight variation during compression. Variation between tablet with respect to dose and weight must be reduced to a minimum.Uniformity of weight is an in process test parameter which ensures consistency of dosage units during compression. Test Procedure Weigh individually 20 units selected at random and calculate the average weight.Not more than two of the individual weights deviates from the average weight by more than the percentage given in the pharmacopea and none deviates by more than twice that percentage.IP/BP & USP limits for tablet weight variation is given below.                                          IP/BP   Limit USP 80 mg or less ± 10% 130mg
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