Pharma approach

1. TABLETS General chapter 2. TABLETS • Tablets are solid dosage form each containing a unit dost of one or more medicament • Intended for oral administration • Some tablets are swallowed whole or after being chewed • some are dissolved or dispersed in water before administration • some are retained in the mouth where the active ingredient is liberated. 3. TABLETS • Because of their composition, method of manufacture or intended use, tablets present a variety of characteristics and consequently there are several categories of tablets. • Unless otherwise stated in the individual monograph, tablets are uncoated. 4. Different types of tablets • Uncoated tablets • Film Coated • Sugar Coated • Dispersible Tablets • Effervescent Tablets • Modified-release Tablets • Enteric-coated Tablets • Prolonged- release Tablets • Soluble Tablets • Tablets for Use in the Mouth

Tablet weight is mainly affected by factors such as tooling of the compression machine,head pressure,machine speed and flow properties of the powder.Inconsistent powder or granulate density and particle size distribution are common sources of weight variation during compression. Variation between tablet with respect to dose and weight must be reduced to a minimum.Uniformity of weight is an in process test parameter which ensures consistency of dosage units during compression. Test Procedure Weigh individually 20 units selected at random and calculate the average weight.Not more than two of the individual weights deviates from the average weight by more than the percentage given in the pharmacopea and none deviates by more than twice that percentage.IP/BP & USP limits for tablet weight variation is given below.                                          IP/BP   Limit USP 80 mg or less ± 10% 130mg

Pharmaceutical packaging (or drug packaging ) is the packages and the packaging processes for pharmaceutical preparations . It involves all of the operations from production through drug distribution channels to the end consumer. Pharmaceutical packaging is highly regulated but with some variation in the details, depending on the country of origin or the region. Several common factors can include: assurance of patient safety, assurance of the efficacy of the drug through the intended shelf life , uniformity of the drug through different production lots, thorough documentation of all materials and processes, control of possible migration of packaging components into the drug, control of degradation of the drug by oxygen, moisture, heat, etc., prevention of microbial contamination, sterility, etc. Packaging is often involved in dispensing, dosing, and use of the pharmaceutical product. Communication of proper use and cautionary labels are also regulated. Packaging is an

1. TABLET COMPRESSION MACHINE 1 Department of Pharmacy (Pharmaceutics)Department of Pharmacy (Pharmaceutics) || Sagar savaleSagar savale Mr. Sagar Kishor SavaleMr. Sagar Kishor Savale Department of Pharmaceutics avengersagar16@gmail.com 2015-016 2. CONTENTS • Introduction • Process of tablet compression Compression and consolidation Decompression Ejection Scrape off • Rotary tablet press design • Mechanism rotary tablet machine • Press design and layout • Troubleshooting • Reference’s 2 3. Introduction • The most common method of drug delivery is oral dosage form of which tablet and capsule are predominant. • Tablet is more accepted as compared to capsule due to many reason such as cost, tamper resistance, ease of handling, ease of identification and manufacturing efficiency. • Tablet compression process understanding is resulted in development of formulation. • Recent advances in the design of tablet compress